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{"type":"standard","title":"2-Aminoethoxydiphenyl borate","displaytitle":"2-Aminoethoxydiphenyl borate","namespace":{"id":0,"text":""},"wikibase_item":"Q4596857","titles":{"canonical":"2-Aminoethoxydiphenyl_borate","normalized":"2-Aminoethoxydiphenyl borate","display":"2-Aminoethoxydiphenyl borate"},"pageid":12049817,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/6/6c/2-APB.png/330px-2-APB.png","width":320,"height":231},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/6/6c/2-APB.png","width":523,"height":377},"lang":"en","dir":"ltr","revision":"1285389375","tid":"be7ada57-1864-11f0-8ddd-a24a7e08cd19","timestamp":"2025-04-13T12:42:22Z","description":"Chemical compound","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/2-Aminoethoxydiphenyl_borate","revisions":"https://en.wikipedia.org/wiki/2-Aminoethoxydiphenyl_borate?action=history","edit":"https://en.wikipedia.org/wiki/2-Aminoethoxydiphenyl_borate?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:2-Aminoethoxydiphenyl_borate"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/2-Aminoethoxydiphenyl_borate","revisions":"https://en.m.wikipedia.org/wiki/Special:History/2-Aminoethoxydiphenyl_borate","edit":"https://en.m.wikipedia.org/wiki/2-Aminoethoxydiphenyl_borate?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:2-Aminoethoxydiphenyl_borate"}},"extract":"2-Aminoethoxydiphenyl borate (2-APB) is a chemical that acts to inhibit both IP3 receptors and TRP channels (although it activates TRPV1, TRPV2, & TRPV3 at higher concentrations). In research it is used to manipulate intracellular release of calcium ions (Ca2+) and modify TRP channel activity, although the lack of specific effects make it less than ideal under some circumstances. Additionally, there is evidence that 2-APB acts directly to inhibit gap junctions made of connexin. Increasing evidence showed that 2-APB is a powerful modifier of store-operated calcium channels (SOC) function, low concentration of 2-APB can enhance SOC while high concentration induces a transient increase followed by complete inhibition.","extract_html":"
2-Aminoethoxydiphenyl borate (2-APB) is a chemical that acts to inhibit both IP3 receptors and TRP channels (although it activates TRPV1, TRPV2, & TRPV3 at higher concentrations). In research it is used to manipulate intracellular release of calcium ions (Ca2+) and modify TRP channel activity, although the lack of specific effects make it less than ideal under some circumstances. Additionally, there is evidence that 2-APB acts directly to inhibit gap junctions made of connexin. Increasing evidence showed that 2-APB is a powerful modifier of store-operated calcium channels (SOC) function, low concentration of 2-APB can enhance SOC while high concentration induces a transient increase followed by complete inhibition.
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